Treatment of hemophagocytic lymphohistiocytosis with. It is the aim of this observation trial to confirm the results of the bnhl bfm 95 trial through an optimized, consistent treatment strategy for children and adolescents. Treatment protocol of the nhlbfm and the nopho study groups. Soluble interleukin2 receptor is a sensitive diagnostic test in adult hlh. From january 1, 1990 to december 31, 2004, a total of. Treatment protocol for hemophagocytic lymphohistiocytosis 2004 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Henter ji1, horne a, arico m, egeler rm, filipovich ah, imashuku s, ladisch s, mcclain k, webb d, winiarski j, janka g. We would like to show you a description here but the site wont allow us. Nhl n11, 3 failures, treatment according to a different protocol due to decision of. The nhl15 protocol is a novel, doseintense, dosedense, sequential.
Hlh in adults is a much more heterogeneous syndrome requiring a more individualized approach depending on the underlying trigger, disease severity and course, as well as genetic background. Treatment of hemophagocytic lymphohistiocytosis with hlh. Management is largely based on hlh 2004 protocol for secondary cases and almost all cases of primary hlh. Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Listing a study does not mean it has been evaluated by the u. Hlh2004 protocol and allogeneic haematopoietic stem cell transplantation.
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